Direct flights between Hanoi and the southernmost province of Ca Mau will be opened by Bamboo Airways on April 29.
Flights will see a frequency of three a week, on Tuesday, Thursday and Saturday.
Departure time in Hanoi is 7.05am and in Ca Mau city 9.55am.
The carrier will use Embraer E190 aircraft for the flights, with each having eight business seats and 90 economy seats.
According to a representative from Bamboo Airways, the lowest one-way price for the flights is initially set at VND769,000 ($32.1) per ticket (excluding taxes and fees).
Ca Mau Airport is capable of handling 200,000 passengers a year.